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Fatal Familial Insomnia (FFI) is a rare brain disease where the patient loses the ability to fall asleep. Prognosis is poor and the inability to sleep is gradually degenerative and eventually fatal.
Fatal familial insomnia is listed as a "rare disease" by the Office of Rare Diseases of the National Institutes of Health. This means that fatal familial insomnia, or a subtype of fatal familial insomnia, affects less than 200,000 people in the U.S. population.