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Fibromyalgia is characterized by pain and/or soreness in the skeletal muscles, tendons, ligaments, etc., that lasts more than three months, poor sleep with morning fatigue and stiffness, and tenderness at 11 of 18 specified sites on the body. The most common painful areas are the low cervical spine, the shoulder, the second rib, the arm, the buttocks and the knee. These symptoms are often worsened by stress or a change in the weather. Depression, which may be due to a chemical imbalance in the brain or the development of chronic pain, is common with fibromyalgia. Virtually all physical activity increases the patient's pain.