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In 2005, the FDA approved the drug Requip (ropinirole) for the treatment of Restless Leg Syndrome (RLS). While this is the first drug specifically approved for RLS, several other drugs have been approved for other conditions and have undergone clinical studies in RLS.
If you do need medication, careful trials may be necessary to find the medicine and dosage that works for you. Keep in mind that no one drug is effective for everyone with RLS. What may be helpful to one individual may actually worsen symptoms for another. And a medicine that worked for you in the past may become ineffective. You should talk with your doctor about RLS before taking any medication.